Am 15.10.2012 19:58, schrieb mariusz doszyń: Hi, I'm not the authority on this, but AFAIR gretl is able to handle the data as long as the machine is "big" enough. So if you have 52K variables and 250 obs, and each datapoint is stored in a double-precision float with 8 bytes, I'd say your memory requirements are 52K*250*8 = roughly 100M, not excessive for today's computers. (Of course, once you start doing calculations, additional memory will be needed to store temporary matrices and stuff, but still.) good luck, sven